What is SPRAVATO® (esketamine) CIII nasal spray?

SPRAVATO® is a prescription medicine, used along with an antidepressant taken by mouth to treat:

– Adults with treatment-resistant depression (TRD)
– Depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions

How will I take SPRAVATO®?

– You will take SPRAVATO® nasal spray yourself, under the supervision of a healthcare provider in a healthcare setting. Your healthcare provider will show you how to use the SPRAVATO® nasal spray device.
– Your healthcare provider will tell you how much SPRAVATO® you will take and when you will take it.
– Follow your SPRAVATO® treatment schedule exactly as your healthcare provider tells you to.
– During and after each use of the SPRAVATO® nasal spray device, you will be checked by a healthcare provider who will decide when you are ready to leave the healthcare setting.
– You will need to plan for a caregiver or family member to drive you home after taking SPRAVATO®.
– If you miss a SPRAVATO® treatment, your healthcare provider may change your dose and treatment schedule.
– Some people taking SPRAVATO® get nausea and vomiting. You should not eat for at least 2 hours before taking SPRAVATO® and not drink liquids at least 30 minutes before taking SPRAVATO®.
– If you take a nasal corticosteroid or nasal decongestant medicine take these medicines at least 1 hour before taking SPRAVATO®.

What should I avoid while taking SPRAVATO®?

Do not drive, operate machinery, or do anything where you need to be completely alert after taking SPRAVATO®. Do not take part in these activities until the next day following a restful sleep.

What is the most important information I should know about SPRAVATO®?

Increased blood pressure. SPRAVATO® can cause a temporary increase in your blood pressure that may last for about 4 hours after taking a dose. Your healthcare provider will check your blood pressure before taking SPRAVATO® and for at least 2 hours after you take SPRAVATO®. Tell your healthcare provider right away if you get chest pain, shortness of breath, sudden severe headache, change in vision, or seizures after taking SPRAVATO®.

Problems with thinking clearly. Tell your healthcare provider if you have problems thinking or remembering.
Bladder problems. Tell your healthcare provider if you develop trouble urinating, such as a frequent or urgent need to urinate, pain when urinating, or urinating frequently at night.

What are the possible side effects of SPRAVATO®?

The most common side effects of SPRAVATO® when used along with an antidepressant taken by mouth include:

– feeling disconnected from yourself, your thoughts, feelings and things around you
– dizziness
– nausea
– feeling sleepy
– spinning sensation
– decreased feeling of sensitivity (numbness)
– feeling anxious
– lack of energy
– increased blood pressure
– vomiting
– feeling drunk
– feeling very happy or excited

If these common side effects occur, they usually happen right after taking SPRAVATO® and go away the same day.

Call your doctor for medical advice about Spravato. 

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